thyroid | Recent Entries

Many, many hypos (and probably a lot of other people too) are d-deficient. Due to where most of us live, how much time we spend inside, and the amount of sunblock/sun lotion we use when we go outside.

D-deficiency symptoms are eerily like hypo-symptoms: muscle pain, weak bones/fractures, low energy and fatigue, lowered immunity, symptoms of depression and mood swings, and sleep irregularities.

It is well worth your while to have your levels of D tested AND getting the numbers, because once again, there is discussion going on whether or not the standard reference ranges are correct. In many places "25" is taken as the lower healthy limit, whilst there is research to indicate that within those same reference ranges 80 is a better number.

freebirds

I'm back once again. You can see my past entry here.

Well, I told my doctor that I'd like to be at a level 2 in my TSH levels since I was supposed to be at a 5 by their prescription. Now they've taken me from 100 mcg to 50 mcg. Is this right?

I've been feeling tired, having trouble losing weight, the usual symptoms of an underactive thyriod. I asked my doctor was that a higher prescription & the nurse said yes. That sounds a bit off, doesn't it?

Thanks in advance for all of the help!

freebirds

Hello. I'm back again.

I'm currently taking 100 mg of Levothyroxine. I've been taking it since April so nearly 4 months. I feel a little better but I still don't feel normal. I've tried taking 150 mg of it but nothing happened.

I'm wondering if I should ask my doctor about taking Liothyronine also or taking Armour? Or am I not taking enough mgs? I'm still tired, I've gained 3 more pounds, still a little forgetful, & still feeling a little grumpy.

I eat all the right things for my thyroid & take my medicine everyday.

My doctor said she wants my levels at 5 but I was at an 8 when she last checked (in April). I'm wondering should I be at a 2 instead?

As I said in my last post, I've been trying for about 10 months now to lose weight & now I've gained so much weight back (with diet & exercise!!) that I've only lost 6 lbs (last time I said I'd lost about 14 lbs). It's so frustrating. I'm 21 years old & I feel like I'm 40.

gwenhyffar

http://www.nature.com/nrendo/journal/v5/n4/full/nrendo.2009.19.html

Effects of thyroid hormones in individual tissues are determined by many factors beyond their serum levels, including local deiodination and expression and activity of thyroid hormone transporters. These effects are difficult to examine by traditional techniques, but a novel approach that exploits the existence of common genetic variants has yielded new and surprising insights. Convincing evidence indicates a role of type 1 iodothyronine deiodinase (D1) in determining the serum T4:T3 ratio and a role of phosphodiesterase 8B in determining TSH levels. In addition, studies of type 2 iodothyronine deiodinase (D2) variants have shown that thyroid hormones contribute to osteoarthritis and these variants influence Intelligence quotient alterations associated with iodine deficiency. Preliminary evidence suggests associations between TSH-receptor variants and fasting glucose level, D1 variants and insulin-like growth factor I production, and D2 variants and hypertension, psychological well-being and response to T3 or T4 treatment. Intriguingly, most of these associations are independent of serum thyroid hormone levels, which highlights the importance of local regulation of thyroid hormones in tissues. Future research might reveal novel roles for thyroid hormones in obesity, cardiovascular disease, osteoporosis and depression and could have implications for interpretation of thyroid function tests and individualization of thyroid hormone replacement therapy.

gwenhyffar

http://www.hotthyroidology.com/editorial_195.html

ABSTRACT
Several drugs inhibit the intestinal absorption of levothyroxine (L-T4) when taken simultaneously with the thyroid hormone or shortly later. Recently, in a study on 8 women, coffee has been reported to reduce the intestinal absorption of L-T4, so that L-T4 was added to the list of the medications whose intestinal absorption is decreased by coffee. We report another six adult patients, 5 women and 1 man, aged 38 to 62 years, who were observed during the last 18 months. All patients were referred because of failure of serum TSH to be normalized or suppressed by appropriate replacement (1.6-1.8 μg/Kg b.w.) or TSH-suppressive (2.0-2.2 μg/Kg b.w.) therapy with L-T4. In each of the six patients, serum TSH failed to be normalized or suppressed if L-T4 was swallowed simultaneously with coffee (or followed by coffee soon after). Correction of this habit, by drinking coffee 60 minutes after having swallowed L-T4 with water, resulted in normalization or suppression of serum TSH.

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The Thyroid

Recent Entries

Vitamin D

(no subject)

More frustrations.

Novel insights into thyroid hormones from the study of common genetic variation

Do you like coffee? And do you love your thyroid?

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May 2010

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